精品国品一二三产品区别在线观看,三人性FREE欧美,亚洲精品国产精品乱码不卡√,精品久久久久久成人av

當前位置:首頁  >  技術文章  >  DUSP1通過MAPKs/NF-κB信號通路介導BCG誘導的THP-1細胞凋亡和炎癥反應

DUSP1通過MAPKs/NF-κB信號通路介導BCG誘導的THP-1細胞凋亡和炎癥反應

更新時間:2024-12-28  |  點擊率:145

20232月,西部特色生物資源保護與利用教育部重點實驗室;寧夏大學生命科學學院;寧夏銀川市賀蘭山路(Key Lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Yinchuan 750021, Ningxia, China;School of Life Sciences, Ningxia University, 539 W.  Helanshan Road, Yinchuan 750021, Ningxia, China) Zhanyou Liu老師研究團隊在《Scientifc Reports》上發(fā)表論文:

DUSP1 mediates BCG induced apoptosis and inflammatory response in THP-1 cells via MAPKs/NF-κB signaling pathway"

 

DUSP1通過MAPKs/NF-κB信號通路介導BCG誘導的THP-1細胞凋亡和炎癥反應"

 

Abstract

Tuberculosis (TB) is a zoonotic infectious disease caused by Mycobacterium tuberculosis (Mtb). Apoptosis and necrosis caused by the interaction between the host and the pathogen, as well as the host's inflammatory response, play an important role in the pathogenesis of TB. Dual-specificity phosphatase 1 (DUSP1) plays a vital role in regulating the host immune responses. However, the role of DUSP1 in the regulation of THP-1 macrophage apoptosis induced by attenuated Mycobacterium bovis Bacillus Calmette-Guérin (BCG) infection remains unclear. In the present study, we report that infection with BCG significantly induces macrophage apoptosis and induces the production of DUSP1, TNF-α and IL-1β. DUSP1 knockdown significantly inhibited BCG-induced macrophage apoptosis and activation of MAPKs/NF-κB signaling pathway. In addition, DUSP1 knockdown suppressed BCG-induced inflammation in vivo. Taken together, this study demonstrates that DUSP1, as a regulator of MAPKs/NF-κB signaling pathway, plays a novel role in BCG-induced macrophage apoptosis and inflammatory response.


摘要:

結核病(TB)是由結核分枝桿菌(Mtb)引起的人畜共患傳染病。宿主與病原體相互作用引起的細胞凋亡和壞死以及宿主的炎癥反應在TB的發(fā)病機制中起著重要作用。雙特異性磷酸酶1 (DUSP1)在調(diào)節(jié)宿主免疫應答中起著至關重要的作用。然而,DUSP1在弱毒牛分枝桿菌卡介苗感染誘導的THP-1巨噬細胞凋亡中的作用尚不清楚。在本研究中,我們報道了卡介苗感染可顯著誘導巨噬細胞凋亡并誘導DUSP1、TNF-αIL-1β的產(chǎn)生。DUSP1基因敲低可顯著抑制bcg誘導的巨噬細胞凋亡和MAPKs/NF-κB信號通路的激活。此外,DUSP1敲低可抑制bcg誘導的體內(nèi)炎癥。綜上所述,本研究表明DUSP1作為MAPKs/NF-κB信號通路的調(diào)節(jié)因子,在bcg誘導的巨噬細胞凋亡和炎癥反應中發(fā)揮了新的作用。

 

該論文中,人髓系白血病單核細胞THP-1細胞的體外培養(yǎng)是使用Ausbian特級胎牛血清完成的。


少妇愉情理伦片高潮日本| 免费网站看v片在线18禁无码| 男女做爰猛烈叫床视频电影| 国产午夜精品久久久久免费视| 亚洲AV无码一区二区一二区| 久久久久国产精品熟女影院| 久久久久99精品成人片三人毛片| 国产精品白浆无码流出| 九九视频免费精品视频| 亚洲国产精品成人综合色在线| 亚洲理论电影在线观看| 无码AⅤ精品一区二区三区| 日本极品粉嫩小泬337p图片| 少妇做爰免费视频网站| 精品久久久久久久换人妻 | 少妇人妻好深太紧了A| 欧美日韩国产精品| 亚洲一区二区女搞男| 成人AV片无码免费网站| 亚洲国产AV无码一区二区三区 | 日本吃奶人妻理论片| 黑人猛挺进小莹的体内视频| 国产又黄又大又粗视频| 免费a级毛片出奶水| 国产国产乱老熟女视频网站97| 国产乱子伦在线观看| 久久精品一区二区三区av| 欧美疯狂做受xxxx高潮| 日韩欧美亚洲国产精品字幕久久久 | 麻豆熟妇人妻XXXXXX| 金瓶梅1电影观看完整版| 日本va欧美va精品发布| 老司机午夜福利视频| 日本一大免费高清| 人妻丰满AV无码久久不卡| 国产真实乱对白精彩久久| 亚洲av午夜精品麻豆av| 在线观看韩国电影| 久久国产乱子伦精品免费女| 欧美精品精品一区在线发布| 激情97综合亚洲色婷婷五 |